Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Endotheliopathy in acute COVID-19 and long COVID

AG Vassiliou, CS Vrettou, C Keskinidou… - International Journal of …, 2023 - mdpi.com
The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

COVID-19 and Long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

Cell-specific mechanisms in the heart of COVID-19 patients

EJ Tsai, D Čiháková, NR Tucker - Circulation research, 2023 - Am Heart Assoc
From the onset of the pandemic, evidence of cardiac involvement in acute COVID-19
abounded. Cardiac presentations ranged from arrhythmias to ischemia, myopericarditis …

Lipid nanoparticles for nucleic acid delivery to endothelial cells

GW Liu, EB Guzman, N Menon, RS Langer - Pharmaceutical Research, 2023 - Springer
Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

JA Adetunji, KD Fasae, AI Awe, OK Paimo… - Heliyon, 2023 - cell.com
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement

M Sayyadi, S Hassani, M Shams, A Dorgalaleh - Annals of Hematology, 2023 - Springer
The coagulation, fibrinolytic, anticoagulation, and complement systems are in delicate
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …

Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality

A Yamazaki, Y Nukui, T Kameda, R Saito, Y Koda… - Scientific Reports, 2023 - nature.com
Abstract Coronavirus disease (COVID-19) has caused extensive mortality globally;
therefore, biomarkers predicting the severity and prognosis of COVID-19 are essential. This …

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia

J Hirsch, G Uzun, J Zlamal, A Singh… - Frontiers in …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis,
particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy …

Extracellular vesicles of COVID-19 patients reflect inflammation, thrombogenicity, and disease severity

A Aharon, A Dangot, F Kinaani, M Zavaro… - International Journal of …, 2023 - mdpi.com
Severe COVID-19 infections present with cytokine storms, hypercoagulation, and acute
respiratory distress syndrome, with extracellular vesicles (EVs) being involved in …