Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based proteomics is a
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Insulin resistance is the main mechanism in a whole series of pathological conditions, which
are not only of metabolic interest but also of a systemic type. This phenomenon means that …

Catalase (CAT) is often phosphorylated and activated by protein kinases to maintain
hydrogen peroxide (H2O2) homeostasis and protect cells against stresses, but whether and …

Highly selective enrichment of low abundance phosphopeptides from intricate biological
samples before mass spectrometry detection is a vital prerequisite for in-depth …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular
patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of …

Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …