Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers,
associated with poor survival outcomes. Lack of early diagnosis, resistance to conventional …

DNA methylation, histone modifications, and non-coding RNAs are ubiquitous in the animal
kingdom. Histone modifications are apparently similar in all higher animal taxa but DNA …

Background Climate change has had a tremendous impact on the environment in general
as well as agricultural crops grown in these situations as time passed. Agricultural …

Despite many advances in treatment over the past few years, the poor 5-year survival rate
and high recurrence rate of gastric cancer (GC) remain unsatisfactory. As the most abundant …

Bone repair remains a clinical challenge due to low osteogenic capacity. Coactivator
associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase …

In addition to the classical role as a serum effector system of innate immunity, accumulating
evidence suggests that intracellular complement components have indispensable functions …

Abstract The World Health Organization (WHO) has identified the obesity epidemic as one of
the leading causes of overall morbidity and mortality. Obesity affects individual health, and …

Neurodevelopment is a complex and finely orchestrated process, deficiencies in which have
major effects on lifelong health outcomes. The epigenetic machinery is a key modulator of …