Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Cancer-associated fibroblasts (CAFs) are abundant and important components of the
tumour mesenchyme, and have been extensively studied for their role in primary tumours …

Background The prognostic management of bladder cancer (BLCA) remains a great
challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a …

Purpose: Adenoid cystic carcinoma (ACC) is a heterogeneous malignancy, and no effective
systemic therapy exists for metastatic disease. We previously described two prognostic ACC …

Current clinical and observational evidence supports the EXTREME regimen as one of the
standards of care for patients with recurrent or metastatic head and neck squamous cell …

Due to their immunosuppressive role, tumor-infiltrating regulatory T cells (TI-Tregs)
represent attractive immuno-oncology targets. Analysis of TI vs. peripheral Tregs (P-Tregs) …

The tumour microenvironment (TME) is critical for the initiation, progression, and metastasis
of tumours, and cancer-associated fibroblasts (CAFs) are the most dominant cells and have …

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most life-
threatening diseases which also causes economic burden worldwide. To overcome the …

Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high
morbidity and mortality, leading to almost half-million deaths annually worldwide. A better …

In the past decade, cancer treatment has been revolutionized by the rise of checkpoint
inhibitor immunotherapies. Traditional approaches to treating cancer have been focused on …