Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has
resulted in the selection of numerous human genetic variants that confer an advantage …

Recent data suggest that only a small fraction of severe malaria heritability is explained by
the totality of genetic markers discovered so far. The extensive genetic diversity within …

Burkina Faso is a malaria-endemic country, with a high incidence of G6PD deficiency
(G6PDd), which recorded its first case of COVID-19 in March 2020. G6PDd leads to a …

Background TP53 has been shown to play a role in inflammatory processes, including
malaria. We previously found that p53 attenuates parasite-induced inflammation and …

Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant
stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the …

Blood group O is associated with protection against severe malaria and reduced size and
stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood …

Background Malaria caused by P. falciparum imposes a tremendous public health burden
on people living in sub-Saharan Africa. Severe malaria is associated with high morbidity and …

Abstract Background Polymorphisms in ATP2B4 coding for PMCA4b, the primary regulator
of erythrocyte calcium concentration, have been shown by GWAS and cross-sectional …

Malaria is a vector-borne infection common in tropical and subtropical countries. The
immunological reactions warranted by the malaria Plasmodium falciparum parasite occur …