Stem cell-based strategies and challenges for production of cultivated meat
Cultivated meat scale-up and industrial production will require multiple stable cell lines from
different species to recreate the organoleptic and nutritional properties of meat from …
different species to recreate the organoleptic and nutritional properties of meat from …
The naked mole-rat as a model for healthy aging
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …
Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals
Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …
the shortest and longest living species. This natural difference may uncover the evolutionary …
Genomics of adaptive evolution in the woolly mammoth
Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …
organisms. However, the identification of species-specific fixed genetic variants requires the …
[HTML][HTML] The evolution of aging and lifespan
S Li, JM Vazquez, PH Sudmant - Trends in Genetics, 2023 - cell.com
Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …
across different species and spans several orders of magnitude in vertebrates alone. This …
miRNA-214-3p stimulates carcinogen-induced mammary epithelial cell apoptosis in mammary cancer-resistant species
RM Harman, SP Das, M Kanke, P Sethupathy… - Communications …, 2023 - nature.com
Mammary cancer incidence varies greatly across species and underlying mechanisms
remain elusive. We previously showed that mammosphere-derived epithelial cells from …
remain elusive. We previously showed that mammosphere-derived epithelial cells from …
The need for evolutionary theory in cancer research
AM Boddy - European Journal of Epidemiology, 2023 - Springer
Abstract Sir Richard Peto is well known for proposing puzzling paradoxes in cancer biology—
some more well-known than others. In a 1984 piece, Peto proposed that after decades of …
some more well-known than others. In a 1984 piece, Peto proposed that after decades of …
Adaptation in the face of internal conflict: the paradox of the organism revisited
The paradox of the organism refers to the observation that organisms appear to function as
coherent purposeful entities, despite the potential for within‐organismal components like …
coherent purposeful entities, despite the potential for within‐organismal components like …
Comparative analysis of bats and rodents' genomes suggests a relation between non-LTR retrotransposons, cancer incidence, and ageing
The presence in nature of species showing drastic differences in lifespan and cancer
incidence has recently increased the interest of the scientific community. In particular, the …
incidence has recently increased the interest of the scientific community. In particular, the …
Ancient segmentally duplicated LCORL retrocopies in equids
K Batcher, S Varney, T Raudsepp, M Jevit, P Dickinson… - PloS one, 2023 - journals.plos.org
LINE-1 is an active transposable element encoding proteins capable of inserting host gene
retrocopies, resulting in retro-copy number variants (retroCNVs) between individuals. Here …
retrocopies, resulting in retro-copy number variants (retroCNVs) between individuals. Here …