An update of epigenetic drugs for the treatment of cancers and brain diseases: a comprehensive review

Z Sahafnejad, S Ramazi, A Allahverdi - Genes, 2023 - mdpi.com
Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Decoding the genetic and epigenetic basis of asthma

BS Stikker, RW Hendriks, R Stadhouders - Allergy, 2023 - Wiley Online Library
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

aaUrgent Needs of Caregiving in Ageing Populations with Alzheimer's Disease and Other Chronic Conditions: Support Our Loved Ones

JW Culberson, J Kopel, U Sehar, PH Reddy - Ageing Research Reviews, 2023 - Elsevier
The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …

Histone modifications in Alzheimer's disease

DA Santana, MAC Smith, ES Chen - Genes, 2023 - mdpi.com
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …

Targeting the molecular & cellular pillars of human aging with exercise

J Goh, E Wong, J Soh, AB Maier… - The FEBS …, 2023 - Wiley Online Library
Biological aging is the main driver of age‐associated chronic diseases. In 2014, the United
States National Institute of Aging (NIA) sponsored a meeting between several investigators …

Genomic instability and epigenetic changes during aging

L López-Gil, A Pascual-Ahuir, M Proft - International Journal of Molecular …, 2023 - mdpi.com
Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

A socioecological-genetic framework of culture and personality: Their roots, trends, and interplay

JG Lu, V Benet-Martínez… - Annual Review of …, 2023 - annualreviews.org
Culture and personality are two central topics in psychology. Individuals are culturally
influenced influencers of culture, yet the research linking culture and personality has been …

[HTML][HTML] Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances

R Mallick, AK Duttaroy - Neurochemistry International, 2023 - Elsevier
Abstract Changes in gene expression are involved in many brain functions. Epigenetic
processes modulate gene expression by histone modification and DNA methylation or RNA …

Methylation-based biological age and hypertension prevalence and incidence

JK Kresovich, DP Sandler, JA Taylor - Hypertension, 2023 - Am Heart Assoc
Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …