Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms
J Meccia, J Lopez, RC Bagot - Psychopharmacology, 2023 - Springer
Interest in the therapeutic potential of serotonergic psychedelic compounds including
psilocybin has surged in recent years. While human clinical research suggests psilocybin …
psilocybin has surged in recent years. While human clinical research suggests psilocybin …
Refinement of the Barnes and Morris water maze protocols improves characterization of spatial cognitive deficits in the lithium-pilocarpine rat model of epilepsy
AV Dyomina, IV Smolensky, AV Zaitsev - Epilepsy & Behavior, 2023 - Elsevier
Temporal lobe epilepsy (TLE) often causes cognitive impairment, especially a decline in
spatial memory. Reductions in spatial memory and learning are also common in rodent …
spatial memory. Reductions in spatial memory and learning are also common in rodent …
“The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of maternal separation
O Stupart, TW Robbins, JW Dalley - Psychopharmacology, 2023 - Springer
Rationale Unconditioned tasks in rodents have been the mainstay of behavioural
assessment for decades, but their validity and sensitivity to detect the behavioural …
assessment for decades, but their validity and sensitivity to detect the behavioural …
Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS-induced depression-like behaviors through downregulation of α2δ-1
C Jiang, C Wang, W Qu, Y Wang, H Wang, X Wei… - Heliyon, 2023 - cell.com
Depression is a complex and prevalent mental illness. Cherry leaf is a traditional Chinese
herbal medicine, which has confirmed to exert a certain antidepressant effect, but its …
herbal medicine, which has confirmed to exert a certain antidepressant effect, but its …
[HTML][HTML] Early-and late-phase changes of brain activity and early-phase neuromodulation in the posttraumatic stress disorder rat model
Posttraumatic stress disorder (PTSD) is a complex syndrome that may occur after life-
threatening events. Fear memory abnormalities may play vital roles in the pathogenesis of …
threatening events. Fear memory abnormalities may play vital roles in the pathogenesis of …
[HTML][HTML] Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression
CA Hales, SA Stuart, J Griffiths, J Bartlett… - …, 2023 - Elsevier
Chronic stress is a known risk factor for the development of major depression (MDD) and is
commonly used to induce a depression-like phenotype in rodents. Similar phenotypic effects …
commonly used to induce a depression-like phenotype in rodents. Similar phenotypic effects …
Cognitive tasks as measures of pig welfare: a systematic review
T Ede, TD Parsons - Frontiers in Veterinary Science, 2023 - frontiersin.org
Cognitive approaches are increasingly used to assess animal welfare, but no systematic
review has been conducted on pigs despite their cognitive capacities. Our aims were two …
review has been conducted on pigs despite their cognitive capacities. Our aims were two …
Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice
Despite the initial successes of the Bacillus Calmette-Guerin (BCG) vaccine in children, its
efficacy against tuberculosis is highly variable. There is a lack of understanding about how …
efficacy against tuberculosis is highly variable. There is a lack of understanding about how …
Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP)
Animal models are important in preclinical psychopharmacology to study mechanisms and
potential treatments for psychiatric disorders. A working group of 14 volunteers, comprising …
potential treatments for psychiatric disorders. A working group of 14 volunteers, comprising …