Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited
treatment options and an incompletely understood pathophysiology. Although genomewide …

Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated
action of multiple protein complexes. While physiological experiments, interaction data, and …

Subthreshold depolarization enhances neurotransmitter release evoked by action potentials
and plays a key role in modulating synaptic transmission by combining analog and digital …

The critical presynaptic protein Munc13 serves numerous roles in the process of docking
and priming synaptic vesicles. Here we investigate the functional significance of two distinct …

Regulated exocytosis is a central mechanism of cellular communication. It is not only the
basis for neurotransmission and hormone release, but also plays an important role in the …

Abstract Background Fragile X syndrome (FXS), the most common inherited intellectual
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …

Background: Synaptic changes occur early in patients with Huntington's disease (HD) and in
mouse models of HD. An analysis of synaptic changes in HD transgenic sheep (OVT73) is …

Presynaptic plasticity adjusts neurotransmitter (NT) liberation. Short-term facilitation (STF)
tunes synapses to millisecond repetitive activation, while presynaptic homeostatic …

Neurotransmitters are released from synaptic and secretory vesicles following calcium-
triggered fusion with the plasma membrane. These exocytotic events are driven by assembly …