Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process
E Neher - Journal of General Physiology, 2023 - rupress.org
Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …
UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target
SW Willemse, P Harley, RPA van Eijk… - Journal of Neurology …, 2023 - jnnp.bmj.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited
treatment options and an incompletely understood pathophysiology. Although genomewide …
treatment options and an incompletely understood pathophysiology. Although genomewide …
Munc13-and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming
C Papantoniou, U Laugks, J Betzin, C Capitanio… - Science …, 2023 - science.org
Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated
action of multiple protein complexes. While physiological experiments, interaction data, and …
action of multiple protein complexes. While physiological experiments, interaction data, and …
L-type Ca2+ channels mediate regulation of glutamate release by subthreshold potential changes
BJ Lee, U Lee, SH Ryu, S Han… - Proceedings of the …, 2023 - National Acad Sciences
Subthreshold depolarization enhances neurotransmitter release evoked by action potentials
and plays a key role in modulating synaptic transmission by combining analog and digital …
and plays a key role in modulating synaptic transmission by combining analog and digital …
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
M Bera, K Grushin, RVK Sundaram, Z Shahanoor… - bioRxiv, 2023 - biorxiv.org
The critical presynaptic protein Munc13 serves numerous roles in the process of docking
and priming synaptic vesicles. Here we investigate the functional significance of two distinct …
and priming synaptic vesicles. Here we investigate the functional significance of two distinct …
Lytic granule exocytosis at immune synapses: lessons from neuronal synapses
Regulated exocytosis is a central mechanism of cellular communication. It is not only the
basis for neurotransmission and hormone release, but also plays an important role in the …
basis for neurotransmission and hormone release, but also plays an important role in the …
The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
R Martín, AS Suárez-Pinilla, N García-Font… - Molecular autism, 2023 - Springer
Abstract Background Fragile X syndrome (FXS), the most common inherited intellectual
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …
disability, is caused by the loss of expression of the Fragile X Messenger Ribonucleoprotein …
Levels of synaptic proteins in brain and neurofilament light chain in cerebrospinal fluid and plasma of OVT73 Huntington's disease sheep support a prodromal disease …
Background: Synaptic changes occur early in patients with Huntington's disease (HD) and in
mouse models of HD. An analysis of synaptic changes in HD transgenic sheep (OVT73) is …
mouse models of HD. An analysis of synaptic changes in HD transgenic sheep (OVT73) is …
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
M Jusyte, N Blaum, MA Böhme, MMM Berns… - Cell Reports, 2023 - cell.com
Presynaptic plasticity adjusts neurotransmitter (NT) liberation. Short-term facilitation (STF)
tunes synapses to millisecond repetitive activation, while presynaptic homeostatic …
tunes synapses to millisecond repetitive activation, while presynaptic homeostatic …
Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission
FA Meunier, Z Hu - Molecular Mechanisms of Neurotransmitter Release, 2023 - Springer
Neurotransmitters are released from synaptic and secretory vesicles following calcium-
triggered fusion with the plasma membrane. These exocytotic events are driven by assembly …
triggered fusion with the plasma membrane. These exocytotic events are driven by assembly …