Decoding enhancer complexity with machine learning and high-throughput discovery
GD Smith, WH Ching, P Cornejo-Páramo, ES Wong - Genome biology, 2023 - Springer
Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …
flexible organization and functional redundancies make deciphering their sequence-function …
Next-generation plasmids for transgenesis in zebrafish and beyond
CL Kemmler, HR Moran, BF Murray… - …, 2023 - journals.biologists.com
Transgenesis is an essential technique for any genetic model. Tol2-based transgenesis
paired with Gateway-compatible vector collections has transformed zebrafish transgenesis …
paired with Gateway-compatible vector collections has transformed zebrafish transgenesis …
Systematic part transfer by extending a modular toolkit to diverse bacteria
KW Keating, EM Young - ACS Synthetic Biology, 2023 - ACS Publications
It is impractical to develop a new parts collection for every potential host organism. It is well-
established that gene expression parts, like genes, are qualitatively transferable, but there is …
established that gene expression parts, like genes, are qualitatively transferable, but there is …
Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea
AP Trigila, VC Castagna, L Berasain… - Molecular Biology …, 2023 - academic.oup.com
The genetic bases underlying the evolution of morphological and functional innovations of
the mammalian inner ear are poorly understood. Gene regulatory regions are thought to …
the mammalian inner ear are poorly understood. Gene regulatory regions are thought to …
[HTML][HTML] Zebrafish for the Study of Enhancer Activity in Human Traits and Disease
E Morice, C Calhoun, R Lalonde… - Zebrafish Research-An …, 2023 - intechopen.com
Enhancers are genetically encoded elements that are critical for controlling gene
expression. Despite the importance of enhancers in development, normal biological …
expression. Despite the importance of enhancers in development, normal biological …
Enhancers display constrained sequence flexibility and context-specific modulation of motif function
F Reiter, BP de Almeida, A Stark - Genome Research, 2023 - genome.cshlp.org
The information about when and where each gene is to be expressed is mainly encoded in
the DNA sequence of enhancers, sequence elements that comprise binding sites (motifs) for …
the DNA sequence of enhancers, sequence elements that comprise binding sites (motifs) for …
Function of the Avian Respiratory System
JN Maina - Current Perspectives on the Functional Design of the …, 2023 - Springer
The gas exchange function of the avian respiratory system is explained. The following
important structural—and functional aspects are presented: the mechanisms of airflow …
important structural—and functional aspects are presented: the mechanisms of airflow …
Promoter element engineering towards modulated and consistent gene expression
KV Presnell - 2023 - repositories.lib.utexas.edu
Metabolic engineering requires precise control over expression strength, which can be
effectively accomplished through engineering of the promoter element. In this regard, there …
effectively accomplished through engineering of the promoter element. In this regard, there …
[PDF][PDF] Domestication of Nonconventional Gram-negative Bacteria as Synthetic Biology Chassis
KW Keating - 2023 - digital.wpi.edu
Bacteria have evolved to thrive in an astonishing range of conditions, to produce chemicals
and materials useful to humans, and to sense and respond to changes in their environment …
and materials useful to humans, and to sense and respond to changes in their environment …