Genetic variant (s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to
mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses …

Background Despite the continued vaccination efforts, there had been a surge in
breakthrough infections, and the emergence of the B. 1.1. 529 omicron variant of SARS-CoV …

Understanding disease burden and transmission dynamics in resource-limited, low-income
countries like Nepal are often challenging due to inadequate surveillance systems. These …

Background Toll-like receptors (TLRs) play an important role in activation of innate and
adaptive immune responses. Aim We aimed to detect the association between TLR2 …

The attachment of SARA‐CoV‐2 happens between ACE2 and the receptor binding domain
(RBD) on the spike protein. Mutations in this domain can affect the binding affinity of the …

Scientists have made great efforts to understand the evolution of SARS-CoV-2 (Severe
Acute Respiratory Syndrome Coronavirus 2) to provide crucial information to public health …

Purpose Omicron (B. 1.1. 529) is one of the highly mutated variants of concern of SARS-CoV-
2. Lineages of Omicron bear a remarkable degree of mutations leading to enhanced …

Understanding the adaptation of SARS-CoV-2 is critical for the development of effective
treatments against this exceptionally successful human pathogen. To predict the emergence …

There are many scientific reports on the interaction of the SARS‐CoV‐2 virus S protein (and
its RBD) with the human ACE2 receptor protein. However, there are no reliable data on how …

The changes in the SARS-CoV-2 genome have resulted in the emergence of new variants.
Some of the variants have been classified as variants of concern (VOC). These strains have …