N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the
therapeutic protocols of cystic fibrosis. NAC is also administered as an antidote in …

Mitochondria are critical organelles responsible for the maintenance of cellular energy
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …

Acute liver failure (ALF) is a rare, acute, potentially reversible condition resulting in severe
liver impairment and rapid clinical deterioration in patients without preexisting liver disease …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …

Developing nanomedicines with superior reactive oxygen species (ROS) scavenging
capability has emerged as a promising strategy in treating ROS‐related diseases, for …

Hepatotoxicity is a serious problem faced by clinical drugs, and long-term administration or
overdose may lead to liver failure and even death of patients. Therefore, developing a …

Leonurine (Leo) is a natural alkaloid isolated from the herb Leonurus japonicus
Houtt.(Leonuri) that has been shown to inhibit oxidative stress and inflammation. However …

Acetaminophen (APAP) overdose can cause severe liver injury and acute liver failure. The
only clinically approved antidote, N‐acetylcysteine (NAC), is highly effective but has a …

Drug-induced liver injury (DILI) is a commonly encountered and diagnostically complex
etiology of acute liver failure, characterized by early indications of hepatic oxidative stress …

AIM To investigate whether SGs could protect hepatocytes from hypoxia-induced damage
during acute liver failure (ALF) by reducing endoplasmic reticulum stress (ERS) mediated …