Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …

Autoinflammatory disorders and autoimmune diseases result from abnormal deviations of
innate and adaptive immunity that heterogeneously affect organs and clinical phenotypes …

RNA 3D structures are critical for understanding their functions. However, only a limited
number of RNA structures have been experimentally solved, so computational prediction …

Pulmonary fibrosis is a chronic and irreversible lung disease with limited therapeutic
regimens. Advances in elucidating the pathophysiological mechanism and discovering …

Recent advances and discoveries in the structure and role of mRNA as well as novel lipid-
based delivery modalities have enabled the advancement of mRNA therapeutics into the …

RNA-based oligonucleotide therapeutics are revolutionizing drug development for disease
treatment. This class of therapeutics differs from small molecules and protein therapeutics in …

Restoring sodium iodide symporter (NIS) expression and function remains a major
challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient …

Hydrophilic interaction chromatography (HILIC) has been proposed as a valuable
alternative to ion-pairing reversed-phase chromatography (IP-RPLC) for oligonucleotide …

In recent years, RNA-based therapies have gained much attention as biomedicines due to
their remarkable therapeutic effects with high specificity and potency. Lung diseases offer a …