T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

CD8+ lymphocytes are adaptive immunity cells with the particular function to directly kill the
target cell following antigen recognition in the context of MHC class I. In addition, CD8+ T …

The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a
hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium …

Background Neuropathic pain (NP) is one of the most common types of chronic pain and
significantly compromises the quality of life. Autophagy is an intracellular catabolic process …

Introduction: Au cours de la neuro-inflammation, les astrocytes, qui font partie intégrante de
l'unité neuro-vasculaire avec les vaisseaux de la barrière hémato-encéphalique (BHE) …

La perturbation de la barrière hémo-encéphalique et la migration des lymphocytes de la
périphérie vers le système nerveux central (SNC) sont des événements précoces dans la …

Presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis (MS)
brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue …

Using multicolor flow cytometry, the main cytotoxic T lymphocytes (Tcyt) subsets were
identified, based on the expression of CD45RA and CD62L in paired samples of peripheral …

ABSTRACT T cell lymphocytes play an essential role in the adaptive immunity. They arise
from the hematopoietic compartment and reach the thymus, where they achieve their …

Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system in which
cells from primarily the adaptive immune system infiltrate the brain and spinal cord, leading …