Background: Very little was known about the molecular pathogenesis of thyroid cancer until
the late 1980s. As part of the Centennial celebration of the American Thyroid Association …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell
subpopulation in the lineage hierarchy that serves as cell of origin for the different TC …

Background: Thyroid cancer, a heterogeneous disease originating from the thyroid gland,
stands as the predominant endocrine malignan-cy worldwide. Despite advances in …

Mutations in the TP53 gene are the most common among genetic alterations in human
cancers, resulting in the formation of mutant p53 protein (mutp53). Mutp53 promotes …

Context.—Thyroid nodules with longitudinal nuclear grooves have been widely regarded as
synonymous with papillary thyroid carcinoma (PTC). Objective.—To study a series of cases …

The understanding of the molecular pathology of endocrine tumors has advanced greatly in
recent years. Increasing utilization of technologies, such as fluorescence in situ …

Background Genomic testing has enhanced pre-surgical decision making for cytologically
indeterminate thyroid nodules, but there remains uncertainty regarding RAS mutations. The …

Anaplastic thyroid cancer (ATC) is the most lethal form of thyroid cancer with a median
survival between 3 to 5 months and accounts for a disproportionate number of thyroid …

L'unità funzionale della tiroide è il follicolo, una struttura delimitata da epitelio cubico
semplice che presenta una cavità centrale in cui si raccoglie la colloide. Il follicolo è …