Pathogenesis and treatment of Sjogren's syndrome: review and update

Q Zhan, J Zhang, Y Lin, W Chen, X Fan… - Frontiers in …, 2023 - frontiersin.org
Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple
lesions. The main manifestations include dryness of the mouth and eyes, along with …

Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies

GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

Biological therapy in systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren's syndrome: evidence-and practice-based guidance

A Marinho, J Delgado Alves, J Fortuna, R Faria… - Frontiers in …, 2023 - frontiersin.org
Systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and Sjögren's
syndrome (SS) are heterogeneous autoimmune diseases. Severe manifestations and …

The role of regulatory T Cells in the onset and progression of primary Sjögren's syndrome

VG Blinova, VI Vasilyev, EB Rodionova, DD Zhdanov - Cells, 2023 - mdpi.com
Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the
loss of self-tolerance mechanisms in various autoimmune diseases, including primary …

Outline of Salivary Gland Pathogenesis of Sjögren's Syndrome and Current Therapeutic Approaches

Y Yura, M Hamada - International Journal of Molecular Sciences, 2023 - mdpi.com
Sjögren's syndrome (SS) is an autoimmune disease characterized by the involvement of
exocrine glands such as the salivary and lacrimal glands. The minor salivary glands, from …

The spectrum of extraglandular manifestations in primary sjögren's syndrome

A Mihai, C Caruntu, C Jurcut, FC Blajut… - Journal of Personalized …, 2023 - mdpi.com
Extraglandular manifestations (EGMs) in primary Sjogren's syndrome (pSS) represent the
clinical expression of the systemic involvement in this disease. EGMs are characterized by a …

Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome

M Li, M Li, L Qiao, C Wu, D Xu, Y Zhao… - Chinese Medical …, 2023 - mednexus.org
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence
and possible poor prognosis. Though the pathogenesis of pSS has not been fully …

Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease

A Akgul, CF Freguia, M Maddaloni, C Hoffman… - Scientific Reports, 2023 - nature.com
Sjögren's Syndrome (SjS) results in loss of salivary and lacrimal gland excretion due to an
autoimmune attack on these secretory glands. Conventional SjS treatments address the …

Emerging treatment for Sjögren's disease: A review of recent phase II and III trials

RI Fox, CM Fox, SS McCoy - Expert Opinion on Emerging Drugs, 2023 - Taylor & Francis
Introduction Sjögren's Disease, SjD, is a systemic autoimmune disorder characterized by
reduced function of the salivary and lacrimal glands. Patients suffer from dryness, fatigue …

French national diagnostic and care protocol for Sjögren's disease

V Devauchelle-Pensec, X Mariette… - La Revue de Médecine …, 2023 - Elsevier
Sjögren's disease (SD), also known as Sjögren's syndrome (SS) or Gougerot-Sjögren's
syndrome in France, is a rare systemic autoimmune disease in its primary form and is …