A comprehensive overview of investigational elastase inhibitors for the treatment of acute respiratory distress syndrome
MG Matera, P Rogliani, J Ora, L Calzetta… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Excessive activity of neutrophil elastase (NE), the main enzyme present in
azurophil granules in the neutrophil cytoplasm, may cause tissue injury and remodeling in …
azurophil granules in the neutrophil cytoplasm, may cause tissue injury and remodeling in …
[HTML][HTML] Immunomodulation-based development engineering for advancing metal soft tissue implants
S Chen, J Shi, G Gao, L Xie, Y Zhang, Z Shan… - Smart Materials in …, 2023 - Elsevier
Metal materials have been widely applied clinically due to their superior mechanical
properties. However, the integration of metallic implants with surrounding soft tissue remains …
properties. However, the integration of metallic implants with surrounding soft tissue remains …
JAK-STAT signaling as an ARDS therapeutic target: Status and future trends
Y Zhang, Z Gao, F Jiang, H Yan, B Yang, Q He… - Biochemical …, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is characterized by noncardiogenic pulmonary
edema. It has a high mortality rate and lacks effective pharmacotherapy. With the outbreak of …
edema. It has a high mortality rate and lacks effective pharmacotherapy. With the outbreak of …
IRE1α/XBP-1 promotes β-catenin signaling activation of airway epithelium in lipopolysaccharide-induced acute lung injury
H Zhang, J Li, X Wang, K Wang, JP Xie, G Chen… - Pulmonary …, 2023 - Elsevier
Background Acute lung injury (ALI), along with the more severe condition--acute respiratory
distress syndrome (ARDS), is a major cause of respiratory failure in critically ill patients with …
distress syndrome (ARDS), is a major cause of respiratory failure in critically ill patients with …
[HTML][HTML] Prolonged inflammatory resolution in allergic asthma relates to dysfunctional interactions between neutrophils and airway epithelium
S Ekstedt, V Lagebro, SK Georén, LO Cardell - Annals of Allergy, Asthma & …, 2023 - Elsevier
Background Allergic asthma is a heterogeneous disorder involving chronic airway
inflammation, reversible airflow limitation, and tissue remodeling, causing chronic airflow …
inflammation, reversible airflow limitation, and tissue remodeling, causing chronic airflow …
IL-1β induces a proinflammatory fibroblast microenvironment that impairs lung progenitors' function
C Ciminieri, ME Woest, NL Reynaert… - American Journal of …, 2023 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by a persistent
inflammatory state in the lungs and defective tissue repair. Although the inflammatory …
inflammatory state in the lungs and defective tissue repair. Although the inflammatory …
Therapeutic reprogramming of bone marrow derived mesenchymal stem cells during influenza infection is mediated by type I interferon signaling and interleukin 11
MM Barroso - 2023 - jlupub.ub.uni-giessen.de
Mesenchymal stem cells (MSC) show promising therapeutic potential in different forms of
acute lung injury. However, it is not clear how MSC sense injury during viral lung infections …
acute lung injury. However, it is not clear how MSC sense injury during viral lung infections …