Inhibition of histone deacetylases attenuates tumor progression and improves immunotherapy in breast cancer

B Lian, X Chen, K Shen - Frontiers in Immunology, 2023 - frontiersin.org
Breast cancer is one of the common malignancies with poor prognosis worldwide. The
treatment of breast cancer patients includes surgery, radiation, hormone therapy …

Evaluating atezolizumab in patients with urinary tract squamous cell carcinoma (AURORA): study protocol for a single arm, open-label, multicentre, phase II clinical …

S Crabb, R Wickens, S Jane-Bibby, D Dunkley… - BMC cancer, 2023 - Springer
Background Bladder and urinary tract cancers account for approximately 21,000 new
diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell …

[HTML][HTML] HDACs 家族在乳腺癌中的研究进展

苑豪芳, 刘震, 达梦婷, 张瑾 - Advances in Clinical Medicine, 2023 - hanspub.org
近年来, 组蛋白去乙酰化酶(Histone Deacetylase; HDACs) 家族在乳腺癌发病机制中的研究备
受关注. HDACs 家族是一个重要的表观遗传学调节因子, 可以去除组蛋白的乙酰基化修饰 …

Breast cancer epigenetics

ETR Torres, RM Connolly - Epigenetic Cancer Therapy, 2023 - Elsevier
Alterations in gene expression due to modifications in histone acetylation and DNA
methylation at promoter regions of genes are the essence of what we refer to as epigenetics …

Heat-shock protein 90 (HSP90) in cell physiology.

A Karmazin - 2023 - dspace.cuni.cz
Heat-shock protein 90 (HSP90) is a molecular chaperone that represents one of the most
important proteins for cellular homeostasis in all life domains. Chaperones are proteins that …

[引用][C] NCI Protocol#: PBTC-047 Local Protocol#: PBTC-047 ClinicalTrials. gov Identifier: NCT02717455 TITLE: Phase 1 Trial of Panobinostat in Children with Diffuse …

J Glod