The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Leptin: A heavyweight player in obesity-related cancers

A Caruso, L Gelsomino, S Panza, FM Accattatis… - Biomolecules, 2023 - mdpi.com
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

P Huang, X Fan, H Yu, K Zhang, H Li, Y Wang… - Journal of Translational …, 2023 - Springer
Endometrial cancer (EC) is a common gynecological cancer that endangers women health.
Although substantial progresses of EC management have been achieved in recent years …

The molecular and genetic interactions between obesity and breast cancer risk

GMA Ajabnoor - Medicina, 2023 - mdpi.com
Breast cancer (BC) is considered the leading cause of death among females worldwide.
Various risk factors contribute to BC development, such as age, genetics, reproductive …

Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women

A Romanos-Nanclares, FK Tabung… - JNCI: Journal Of The …, 2023 - academic.oup.com
Background Although unopposed estrogen exposure is considered a major driver of
endometrial carcinogenesis, chronic inflammation and insulin resistance and …

Body mass index and cancer risk: an umbrella review of meta-analyses of observational studies

J Chen, K Ke, Z Liu, L Yang, L Wang, J Zhou… - Nutrition and …, 2023 - Taylor & Francis
Increasing evidence indicates that obesity is a risk factor for various tumors. We aimed to
clarify the evidence for an association between body mass index (BMI) and cancer risk …

The association of serum C-peptide with the risk of cardiovascular events: a meta-analysis and systematic review

MK Jahromi, H Ahmadirad, S Jamshidi… - Diabetology & Metabolic …, 2023 - Springer
Background C-peptide is considered a peptide with active function in the body, which can
affect people's health. However, the results of previous studies on the possible association …

Endometrial telomerase activity in women with either endometrial cancer or hyperplasia: A systematic review and meta-analysis

FR Pérez-López, JR Ulloque-Badaracco… - Maturitas, 2023 - Elsevier
Aim We performed a systematic review and meta-analysis to assess whether endometrial
telomerase activity is associated with endometrial cancer or hyperplasia. Methods PubMed …

Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer

W Tan, J Zhang, Z Deng, F Dai, L Tang, W Hu… - Cancer …, 2023 - Wiley Online Library
Background Numerous studies have shown that the insulin‐like growth factor (IGF) pathway
is highly associated with tumor initial and progression in several tumors. However …

Sonographic, Demographic, and Clinical Characteristics of Pre-and Postmenopausal Women with Endometrial Cancer; Results from a Post Hoc Analysis of the IETA4 …

RW Green, D Fischerová, AC Testa, D Franchi… - Diagnostics, 2023 - mdpi.com
In this study, we conducted a comparative analysis of demographic, histopathological, and
sonographic characteristics between pre-and postmenopausal women diagnosed with …