[HTML][HTML] Meiotic chromosome structure, the synaptonemal complex, and infertility

IR Adams, OR Davies - Annual Review of Genomics and …, 2023 - annualreviews.org
In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein
structure, the synaptonemal complex (SC), that assembles between homologous …

Testis‐specific serine kinase 3 is required for sperm morphogenesis and male fertility

K Nozawa, TX Garcia, K Kent, M Leng, A Jain… - …, 2023 - Wiley Online Library
Background The importance of phosphorylation in sperm during spermatogenesis has not
been pursued extensively. Testis‐specific serine kinase 3 (Tssk3) is a conserved gene, but …

The AnnotSV webserver in 2023: updated visualization and ranking

V Geoffroy, JB Lamouche, T Guignard… - Nucleic Acids …, 2023 - academic.oup.com
Much of the human genetics variant repertoire is composed of single nucleotide variants
(SNV) and small insertion/deletions (indel) but structural variants (SV) remain a major part of …

[HTML][HTML] Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects

Q Li, L Zhao, Y Zeng, Y Kuang, Y Guan, B Chen, S Xu… - Genome Biology, 2023 - Springer
Background Oocyte maturation arrest and early embryonic arrest are important reproductive
phenotypes resulting in female infertility and cause the recurrent failure of assisted …

[HTML][HTML] DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia

AK Dicke, A Pilatz, MJ Wyrwoll, M Punab… - Communications …, 2023 - nature.com
Non-obstructive azoospermia, the absence of sperm in the ejaculate due to disturbed
spermatogenesis, represents the most severe form of male infertility. De novo microdeletions …

The '-ics' of male reproduction: genomics, epigenetics, proteomics, metabolomics, and microbiomics

C Kang, R Bertolla, R Pagani - Current opinion in urology, 2023 - journals.lww.com
Infertility is a common problem for couples with approximately half of cases attributable to
male factor infertility. Although advances in assisted reproductive technology have permitted …

[HTML][HTML] Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

D Dacheux, G Martinez, CEB Reix, J Beurois, P Lorès… - Elife, 2023 - elifesciences.org
Male infertility is common and complex, presenting a wide range of heterogeneous
phenotypes. Although about 50% of cases are estimated to have a genetic component, the …

[HTML][HTML] Deciphering the therapeutic role of Kigelia africana fruit in erectile dysfunction through metabolite profiling and molecular modelling

F Olawale, K Olofinsan, OM Ogunyemi… - Informatics in Medicine …, 2023 - Elsevier
Kigelia africana herbal products are often used traditionally to treat erectile dysfunction and
other sexual complaints, but the underlying mechanism is not yet understood. This study …

Comparison of genetic profiles of neonates in intensive care units conceived with or without assisted reproductive technology

Z Huang, F Xiao, H Xiao, Y Lu, L Yang… - JAMA Network …, 2023 - jamanetwork.com
Importance A growing number of children are conceived with assisted reproductive
technology (ART). However, there is a lack of studies systematically analyzing the genetic …

[HTML][HTML] Comprehensive Transcriptome Analysis in the Testis of the Silkworm, Bombyx mori

K Kakino, H Mon, T Ebihara, M Hino, A Masuda… - Insects, 2023 - mdpi.com
Simple Summary Spermatogenesis, an important process in reproduction, is conserved
across species but has unique aspects in silkworms, such as the maintenance of the …