[HTML][HTML] Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases
J Pan, CJ Fei, Y Hu, XY Wu, L Nie, J Chen - Zoological Research, 2023 - ncbi.nlm.nih.gov
The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …
Regulation of cGAS-STING signalling in cancer: approach for combination therapy
H Vasiyani, B Wadhwa, R Singh - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Innate immunity plays an important role not only during infection but also homeostatic role
during stress conditions. Activation of the immune system including innate immune response …
during stress conditions. Activation of the immune system including innate immune response …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
Mendelian randomization analysis suggests no associations of herpes simplex virus infections with systemic lupus erythematosus
MJ Chang, MT Liu, MR Chen, N Li… - Journal of Medical …, 2023 - Wiley Online Library
Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more
vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively …
vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively …
[HTML][HTML] Understanding nucleic acid sensing and its therapeutic applications
LZ Kong, SM Kim, C Wang, SY Lee, SC Oh… - … & Molecular Medicine, 2023 - nature.com
Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …
[HTML][HTML] Significance of the cGAS-STING Pathway in Health and Disease
J Zhou, Z Zhuang, J Li, Z Feng - International Journal of Molecular …, 2023 - mdpi.com
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …
[HTML][HTML] Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma
Oncolytic viral (OV) therapies are promising novel treatment modalities for cancers refractory
to conventional treatment, such as glioblastoma, within the central nervous system (CNS) …
to conventional treatment, such as glioblastoma, within the central nervous system (CNS) …
[HTML][HTML] How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?
W Zheng, N Chen, F Meurens, W Zheng… - International Journal of …, 2023 - mdpi.com
cGAS is a cytosolic DNA sensor that activates innate immune responses by producing the
second messenger 2′ 3′-cGAMP, which activates the adaptor STING. cGAS senses …
second messenger 2′ 3′-cGAMP, which activates the adaptor STING. cGAS senses …
SUMOylation and DeSUMOylation: Prospective therapeutic targets in cancer
W Wu, C Huang - Life Sciences, 2023 - Elsevier
The SUMO family is a type of ubiquitin-like protein modification molecule. Its protein
modification mechanism is similar to that of ubiquitination: both involve modifier-activating …
modification mechanism is similar to that of ubiquitination: both involve modifier-activating …
cGAS-STING 信号通路: 结构, 调控机制和相关疾病
潘婧， 费辰杰， 胡洋， 吴翔宇， 聂力， 陈炯 - 动物学研究, 2023 - zoores.ac.cn
先天免疫系统是宿主免疫防御的第一道防线, 其通过多种机制保护宿主抵御外源病原入侵及内源
损伤. cGAS-STING 信号通路是先天免疫的重要通路之一, 其由环磷酸鸟苷-磷酸腺苷酸合成酶 …
损伤. cGAS-STING 信号通路是先天免疫的重要通路之一, 其由环磷酸鸟苷-磷酸腺苷酸合成酶 …