Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Hemodynamic overload and dysregulation of cellular metabolism are involved in
development of calcific aortic valve disease (CAVD). However, how mechanical stress …

Microtubules are noncovalent polymers built from αβ-tubulin dimers. The disordered C-
terminal tubulin tails are functionalized with multiple glutamate chains of variable lengths …

Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …

Microtubules play an important role in regulating several vital cellular activities, including
cell division and tissue organization, through their dynamic protofilament network. In …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …