Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking
genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …

Metatranscriptomics generates large volumes of sequence data about transcribed genes in
natural environments. Taxonomic annotation of these datasets depends on availability of …

ABSTRACT Introduction Human African Trypanosomiasis is a neglected disease caused by
infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are …

According to both definitions of US Centers for Disease Control and Prevention and World
Health Organization, Neglected Tropical Diseases (NTDs) are a group of preventable and …

Long-term immune evasion by the African trypanosome is achieved through repetitive cycles
of surface protein replacement with antigenically distinct versions of the dense Variant …

Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to
nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria …