Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Loss and gain of functions mutations in the X-linked MECP2 (methyl-CpG-binding protein 2)
gene are responsible for a set of generally severe neurological disorders that can affect both …

Alzheimer's disease (AD) is the most common form of dementia, and both the incidence of
this disease and its associated cognitive decline disproportionally effect women. While the …

Human cortex transcriptomic studies have revealed a hierarchical organization of γ-
aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of …

The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …

Electrical neurostimulation is effective in the treatment of neurological disorders, but
associated recording artefacts generally limit its applications to open-loop stimuli. Real-time …

Interhemispheric communication through the corpus callosum is required for both sensory
and cognitive processes. Impaired transcallosal inhibition causing interhemispheric …

The mammalian brain is composed of many brain structures, each with its own ontogenetic
and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 …

Stress has profound effects on fear extinction, a form of learning that is essential to
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …