[HTML][HTML] Endothelial to mesenchymal transition in health and disease

Y Xu, JC Kovacic - Annual Review of Physiology, 2023 - annualreviews.org
The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …

Endothelial cell plasticity in kidney fibrosis and disease

L Pohl, IM Schiessl - Acta Physiologica, 2023 - Wiley Online Library
Renal endothelial cells demonstrate an impressive remodeling potential during angiogenic
sprouting, vessel repair or while transitioning into mesenchymal cells. These different …

Targeting epsins to inhibit fibroblast growth factor signaling while potentiating transforming growth factor-β signaling constrains endothelial-to-mesenchymal transition …

Y Dong, B Wang, M Du, B Zhu, K Cui, K Li, K Yuan… - Circulation, 2023 - Am Heart Assoc
Background: Epsin endocytic adaptor proteins are implicated in the progression of
atherosclerosis; however, the underlying molecular mechanisms have not yet been fully …

Multiscale Structure and Function of the Aortic Valve Apparatus

H El-Nashar, M Sabry, YT Tseng… - Physiological …, 2023 - journals.physiology.org
While studying the aortic valve in isolation has facilitated the development of life-saving
procedures and technologies, the dynamic interplay of the aortic valve and its surrounding …

[HTML][HTML] Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-β Signaling Constrains Endothelial-to-Mesenchymal-Transition in Atherosclerosis

Y Dong, B Wang, M Du, B Zhu, K Cui, K Li, K Yuan… - Circulation, 2023 - ncbi.nlm.nih.gov
BACKGROUND: Epsin endocytic adaptor proteins are implicated in the progression of
atherosclerosis; however, the underlying molecular mechanisms have not yet been fully …

[HTML][HTML] Single-cell RNA sequencing reveals the diversity and biology of valve cells in cardiac valve disease

M Fu, J Song - Journal of Cardiology, 2023 - Elsevier
From highly aligned extracellular fibrils to the cells, a multilevel ordered hierarchy in valve
leaflets is crucial for their biological function. Cardiac valve pathology most frequently …