Trauma is the number one cause of death among Americans between the ages of 1 and 46
years, costing more than $670 billion a year. Following death related to central nervous …

BACKGROUND Balanced transfusion is lifesaving for hemorrhagic shock. The American
Red Cross critical blood shortage in 2022 threatened the immediate availability of blood. To …

Hemorrhagic shock in pediatric trauma patients remains a challenging yet preventable
cause of death. There is little high-quality evidence available to guide specific aspects of …

This study aimed to evaluate the efficacy of perioperative intravenous TXA in reducing blood
loss in pelvic and acetabular fracture patients managed surgically. The study included 306 …

BACKGROUND In the Study of Tranexamic Acid During Air and Ground Prehospital
Transport (STAAMP) Trial, prehospital tranexamic acid (TXA) was associated with lower …

Burn injury causes a coagulopathy that is poorly understood. After severe burns, significant
fluid losses are managed by aggressive resuscitation that can lead to hemodilution. These …

Even with extensive transfusion support, trauma-induced bleeding often leads to death.
Early intervention may improve outcomes, yet which blood products, factor concentrates, or …

Objectives Landmark studies published near the turn of the 21st century found an
implementation gap concerning the effect of evidenced-based findings on clinical practice …

As the US military pivots from years of low-intensity counterinsurgency operations to
preparation for large-scale combat operations against a near-peer competitor, the realities of …

Abstract The American Trial Using Tranexamic Acid (TXA) in Thrombocytopenia (A-TREAT,
NCT02578901) demonstrated no superiority of TXA over placebo in preventing World …