[HTML][HTML] Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

[HTML][HTML] Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics

F Zhong, Y Lin, L Zhao, C Yang, Y Ye… - British Journal of Cancer, 2023 - nature.com
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …

[HTML][HTML] Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia

H Wang, Y Qiu, H Zhang, N Chang, Y Hu, J Chen… - Cell Death & …, 2023 - nature.com
B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological disorder with a
dismal prognosis. The dysregulation of histone acetylation is of great significance in the …

[HTML][HTML] Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC

W Xue, W Jian, Y Meng, T Wang, L Cai, Y Yu… - Cell Death & …, 2023 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is
associated with poor prognosis. The histone H3 lysine 36 methyltransferase SET-domain …

[HTML][HTML] TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

T Song, S Lv, X Ma, X Zhao, L Fan, Q Zou, N Li… - Journal of Biological …, 2023 - ASBMB
Autophagy plays a pivotal role in physiology and pathophysiology, including cancer.
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of …

[HTML][HTML] ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma

T Li, L Xu, Z Wei, S Zhang, X Liu, Y Yang, Y Gu… - Molecular cancer, 2023 - Springer
Background Renal cell carcinoma (RCC) is a common malignant tumor of the urinary
system. Angiogenesis is a main contributing factor for tumorigenesis. E74-like transcription …

[HTML][HTML] Advances and challenges in thyroid cancer: The interplay of genetic modulators, targeted therapies, and AI-driven approaches

S Bhattacharya, RK Mahato, S Singh, GK Bhatti… - Life Sciences, 2023 - Elsevier
Thyroid cancer continues to exhibit a rising incidence globally, predominantly affecting
women. Despite stable mortality rates, the unique characteristics of thyroid carcinoma …

RNA N6‐methyladenosine modifications and potential targeted therapeutic strategies in kidney disease

WJ Ni, H Lu, NN Ma, BB Hou, J Zeng… - British Journal of …, 2023 - Wiley Online Library
Epigenetic modifications have received increasing attention and have been shown to be
extensively involved in kidney development and disease progression. Among them, the …

Interplay of phytohormones and epigenetic regulation: A recipe for plant development and plasticity

K Jiang, H Guo, J Zhai - Journal of Integrative Plant Biology, 2023 - Wiley Online Library
Both phytohormone signaling and epigenetic mechanisms have long been known to play
crucial roles in plant development and plasticity in response to ambient stimuli. Indeed …

[HTML][HTML] Protein acetylation and related potential therapeutic strategies in kidney disease

X Li, J Yu, Y Dong, X Shen, R Hou, M Xie, J Wei… - Pharmacological …, 2023 - Elsevier
Kidney disease can be caused by various internal and external factors that have led to a
continual increase in global deaths. Current treatment methods can alleviate but do not …