[HTML][HTML] Mitochondrial heterogeneity in diseases

L Chen, M Zhou, H Li, D Liu, P Liao, Y Zong… - … and Targeted Therapy, 2023 - nature.com
As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

[HTML][HTML] Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

J Zhong, X He, X Gao, Q Liu, Y Zhao, Y Hong… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

[HTML][HTML] Β-hydroxybutyrate: A crucial therapeutic target for diverse liver diseases

K Li, W Wang, J Wu, W Xiao - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract β-hydroxybutyrate (β-HB), the most abundant ketone body, is produced primarily in
the liver and acts as a substitute energy fuel to provide energy to extrahepatic tissues in the …

[HTML][HTML] Biochemistry, ketogenesis

KK Dhillon, S Gupta - Statpearls [internet], 2023 - ncbi.nlm.nih.gov
Ketogenesis is a metabolic pathway that produces ketone bodies, which provide an
alternative form of energy for the body. The body is constantly producing small amounts of …

[HTML][HTML] Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver

X Fu, JA Fletcher, S Deja… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated,
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …

[HTML][HTML] Myosteatosis: diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease

G Henin, A Loumaye, IA Leclercq, N Lanthier - JHEP Reports, 2023 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) sets an increased risk of
multisystemic complications, including muscle changes with sarcopenia and more recently …

[HTML][HTML] Mitochondrial dysfunction-associated mechanisms in the development of chronic liver diseases

MK Arumugam, T Gopal, RR Kalari Kandy… - Biology, 2023 - mdpi.com
Simple Summary Mitochondria are crucially important organelles involved in various
metabolic activities, including energy generation. The involvement of mitochondrial …

[HTML][HTML] Therapeutic Fasting in Reducing Chemotherapy Side Effects in Cancer Patients: A Systematic Review and Meta-Analysis

Y Ferro, S Maurotti, MG Tarsitano, O Lodari, R Pujia… - Nutrients, 2023 - mdpi.com
The aim of this study was to assess the available evidence regarding the effect of a variety of
fasting-like regimens on preventing chemotherapy-related side effects. PubMed, Scopus …

[HTML][HTML] Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis

XZ Zou, JF Hao, MX Hou - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
The respiratory and cardiovascular systems are often the most severely impacted by the
rapid onset of sepsis, which can lead to multiple organ failure. The mortality has ranged from …

[HTML][HTML] Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

G Semmler, C Datz, M Trauner - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
Nutrition and dietary interventions are a central component in the pathophysiology, but also
a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD) …