Human circulating and tissue-resident memory CD8+ T cells

M Buggert, DA Price, LK Mackay, MR Betts - Nature Immunology, 2023 - nature.com
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

[HTML][HTML] Technology meets TILs: Deciphering T cell function in the-omics era

WH Hudson, A Wieland - Cancer cell, 2023 - cell.com
T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection

B Zhang, R Upadhyay, Y Hao, MI Samanovic… - Nature …, 2023 - nature.com
The immune response to SARS-CoV-2 antigen after infection or vaccination is defined by
the durable production of antibodies and T cells. Population-based monitoring typically …

[HTML][HTML] Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy: a comprehensive review

M Li, M Zhang, Q Ye, Y Liu, W Qian - Cancer biology & medicine, 2023 - ncbi.nlm.nih.gov
Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an
ability to elicit curative effects via systemic administration. Tumor cells often create an …

[HTML][HTML] Phase I/II study of PexaVec in combination with immune checkpoint inhibition in refractory metastatic colorectal cancer

C Monge, C Xie, Y Myojin, K Coffman… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Oncolytic immunotherapy represents a unique therapeutic platform for the
treatment of cancer. Here, we evaluated the safety and efficacy of the combination of …

Cross-reactive immune responses to monkeypox virus induced by MVA vaccination in mice

F Gao, C He, M Liu, P Yuan, S Tian, M Zheng, L Zhang… - Virology Journal, 2023 - Springer
Mpox (monkeypox) infection cases increased recently in non-Mpox outbreak areas,
potentially causing an international threat. The desire to defend against a potential outbreak …

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

M Santopaolo, M Gregorova, F Hamilton, D Arnold… - Elife, 2023 - elifesciences.org
Abstract Coronavirus disease-19 (COVID-19) causes immune perturbations which may
persist long term, and patients frequently report ongoing symptoms for months after …

Methods to Assess Proliferation of Stimulated Human Lymphocytes In Vitro: A Narrative Review

N Ganesan, S Ronsmans, P Hoet - Cells, 2023 - mdpi.com
The ability to monitor lymphocyte responses is critical for developing our understanding of
the immune response in humans. In the current clinical setting, relying on the metabolic …

Short-and long-interval prime-boost vaccination with the candidate vaccines MVA-SARS-2-ST and MVA-SARS-2-S induces comparable humoral and cell-mediated …

G Kalodimou, S Jany, A Freudenstein, JH Schwarz… - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused significant human health and economic consequences.
Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and …

The prospective outcome of the monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology

MS Qudus, X Cui, M Tian, U Afaq, M Sajid… - Frontiers in Cellular …, 2023 - frontiersin.org
A new threat to global health re-emerged with monkeypox's advent in early 2022. As of
November 10, 2022, nearly 80,000 confirmed cases had been reported worldwide, with …