Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

The activities of RNA polymerases shape the epigenetic landscape of genomes with
profound consequences for genome integrity and gene expression. A fundamental event …

Histones shape chromatin structure and the epigenetic landscape. H1, the most diverse
histone in the human genome, has 11 variants. Due to the high structural similarity between …

The eQTL Catalogue is an open database of uniformly processed human molecular
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …

How the noncoding genome affects cellular functions is a key biological question. A
particular challenge is to distinguish the effects of noncoding DNA elements from long …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …

Background Alternative splicing (AS), a posttranscriptional process, contributes to the
complexity of transcripts from a limited number of genes in a genome, and AS is considered …

Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in
eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA). As …

The fidelity of splice site selection is critical for proper gene expression. In particular, proper
recognition of 3′-splice site (3′ SS) sequences by the spliceosome is challenging …