Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Methyl donors such as choline, betaine, folic acid, methionine, and vitamins B6 and B12 are
critical players in the one-carbon metabolism and have neuroprotective functions. The one …

Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival,
and treatment options are limited. Antitumor immune memory plays a critical role in …

IDH1 mutations frequently occur early in human glioma. While IDH1 mutation has been
shown to promote gliomagenesis via DNA and histone methylation, little is known regarding …

Intracellular vesicular transport along cytoskeletal filaments ensures targeted cargo delivery.
Such transport is rarely unidirectional but rather bidirectional, with frequent directional …

Inferring the chronological and biological age of individuals is fundamental to population
ecology and our understanding of ageing itself, its evolution, and the biological processes …

Attenuating the Taxol productivity of fungi with the subculturing and storage under axenic
conditions is the challenge that halts the feasibility of fungi to be an industrial platform for …

The cells of multicellular organisms are genetically homogeneous but heterogenous in
structure and function by virtue of differential gene expression. During embryonic …

Epigenetic processes have become increasingly relevant in understanding disease-
modifying mechanisms. 5-Methylcytosine methylations of DNA (5mC) and RNA (m5C) have …

Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial
joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it …