[HTML][HTML] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Genetic determinism, essentialism and reductionism: semantic clarity for contested science
KP Harden - Nature Reviews Genetics, 2023 - nature.com
Research linking genetic differences with human social and behavioural phenotypes has
long been controversial. Frequently, debates about the ethical, social and legal implications …
long been controversial. Frequently, debates about the ethical, social and legal implications …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
[HTML][HTML] Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder
Biobanks often contain several phenotypes relevant to diseases such as major depressive
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
[HTML][HTML] Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci
G Mignogna, CE Carey, R Wedow, N Baya… - Nature Human …, 2023 - nature.com
Response to survey questionnaires is vital for social and behavioural research, and most
analyses assume full and accurate response by participants. However, nonresponse is …
analyses assume full and accurate response by participants. However, nonresponse is …
The roles of social–emotional skills in students' academic and life success: A multi-informant and multicohort perspective.
Social–emotional skills have been shown to be beneficial for many important life outcomes
for students. However, previous studies on the topic have suffered from many issues (eg …
for students. However, previous studies on the topic have suffered from many issues (eg …
[HTML][HTML] Genetic associations with parental investment from conception to wealth inheritance in six cohorts
Genetic inheritance is not the only way parents' genes may affect children. It is also possible
that parents' genes are associated with investments into children's development. We …
that parents' genes are associated with investments into children's development. We …
[HTML][HTML] How to get things done: Tight linkage of conscientiousness with twelve mechanisms of Goal Setting Theory
TC Bates, T Enkhbat, E Gray, J Lee… - Personality and Individual …, 2023 - Elsevier
Conscientiousness (C) is manifested in orderly, responsible, industrious, ambitious, dutiful,
and rule-abiding behavior and in desired outcomes as diverse as work, health, and …
and rule-abiding behavior and in desired outcomes as diverse as work, health, and …
[HTML][HTML] The impact of rare protein coding genetic variation on adult cognitive function
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …