Recent advances in non-small cell lung cancer targeted therapy; an update review

M Araghi, R Mannani, A Heidarnejad maleki… - Cancer Cell …, 2023 - Springer
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …

At the crossroads of immunotherapy for oncogene-addicted subsets of NSCLC

I Otano, AC Ucero, J Zugazagoitia… - Nature reviews Clinical …, 2023 - nature.com
Non-small-cell lung cancer (NSCLC) has become a paradigm of precision medicine, with
the discovery of numerous disease subtypes defined by specific oncogenic driver mutations …

Agnostic approvals in oncology: getting the right drug to the right patient with the right genomics

V Tateo, PV Marchese, V Mollica, F Massari… - Pharmaceuticals, 2023 - mdpi.com
(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

[HTML][HTML] Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

H Padinharayil, J Varghese, MC John, GK Rajanikant… - Genes & …, 2023 - Elsevier
Continuous revision of the histologic and stage-wise classification of lung cancer by the
World Health Organization (WHO) provides the foundation for therapeutic advances by …

Understanding and targeting resistance mechanisms in cancer

ZN Lei, Q Tian, QX Teng, JND Wurpel, L Zeng… - MedComm, 2023 - Wiley Online Library
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Targeted therapy for cancers: from ongoing clinical trials to FDA-approved drugs

HY Choi, JE Chang - International Journal of Molecular Sciences, 2023 - mdpi.com
The development of targeted therapies has revolutionized cancer treatment, offering
improved efficacy with reduced side effects compared with traditional chemotherapy. This …

Targeted therapy for lung cancer: Beyond EGFR and ALK

M Herrera‐Juárez, C Serrano‐Gómez… - Cancer, 2023 - Wiley Online Library
Precision oncology comprises the set of strategies that aim to design the best cancer
treatment based on tumor biology. A recognized subset of patients with non‐small cell lung …

Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer

T Sakamoto, T Matsubara, T Takahama… - JAMA Network …, 2023 - jamanetwork.com
Importance Biomarker testing for driver mutations is essential for selecting appropriate non–
small cell lung cancer (NSCLC) treatment but is insufficient. Objective To investigate the …

[HTML][HTML] EGFR exon 20 insertion mutations and ERBB2 mutations in lung cancer: a narrative review on approved targeted therapies from oral kinase inhibitors to …

D Sentana-Lledo, E Academia, H Viray… - Translational Lung …, 2023 - ncbi.nlm.nih.gov
EGFR exon 20 insertion mutations and ERBB2 mutations in lung cancer: a narrative review
on approved targeted therapies from oral kinase inhibitors to antibody-drug conjugates - PMC …

Liquid biopsies in lung cancer

M Kemper, C Krekeler, K Menck, G Lenz, G Evers… - Cancers, 2023 - mdpi.com
Simple Summary Liquid biopsy has recently been introduced as a novel method in cancer
diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay …