The cardiovascular system requires iron to maintain its high energy demands and metabolic
activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and …

Hypertension is a leading cause of heart failure and other cardiovascular diseases. Its role
in the pathogenesis of heart failure with reduced ejection fraction (HFrEF) differs from that in …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Abstract Background Mesenchymal precursor cells (MPCs) are allogeneic, immunoselected
cells with anti-inflammatory properties that could improve outcomes in heart failure with …

Introduction Heart failure (HF) is usually the end stage of the continuum of various
cardiovascular diseases. However, the mechanism underlying the progression and …

Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in
energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes …

Background Systemic chronic inflammation (SCI) is closely involved in the pathogenesis of
many diseases. This study aims to investigate the association between MLR with mortality …

Chronic inflammation is associated with increased risk and poor prognosis of heart failure;
however, the precise mechanism that provokes sustained inflammation in the failing heart …

The term “inflammageing” was introduced in 2000, with the aim of describing the chronic
inflammatory state typical of elderly individuals, which is characterized by a combination of …

Background Traditional observational studies have shown positive associations between c-
reactive protein (CRP) and heart failure (HF) risk. However, this association has not been …