Abstract Purpose of Review Osteocytes directly modify the bone surrounding the expansive
lacunar-canalicular system (LCS) through both resorption and deposition. The existence of …

Aim Effective biomarkers for estimating glioma prognosis are deficient. Canonically, caspase-
3 acts as an “apoptosis executioner”. However, its prognostic role in glioma and mechanistic …

Engineered living materials (ELMs) are a new class of materials synthesized and/or
populated by living organisms. ELMs have the potential to reduce energy costs in …

Bone fragility is a profound complication of type 1 diabetes mellitus (T1DM), increasing
patient morbidity. Within the mineralized bone matrix, osteocytes build a mechanosensitive …

Mechanical unloading causes rapid loss of bone structure and strength, which gradually
recovers after resuming normal loading. However, it is not well established how this …

Osteocytes sense mechanical loads and transduce mechanical signals into a chemical
response. They are the most abundant bone cells deeply embedded in mineralized bone …

Bone tissue changes substantially in mass and shape during growth. During fetal
development, the genome provides positional information for the skeletal outline through …

Autophagy is an important mechanosensitive response for cellular homeostasis and survival
in osteocytes. However, the mechanism and its effect on bone metabolism have not yet …

Objective It is unclear if different factors influence osteoarthritis (OA) progression and
degenerative changes characterising OA disease in hip and knee. We investigated the …

Bcl2l1 (Bcl-XL) belongs to the Bcl-2 family, Bcl2 and Bcl2-XL are major anti-apoptotic
proteins, and the apoptosis of osteoblasts is a key event for bone homeostasis. As the …