Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

RS Pereira, FCP Santos, PRV Campana, VV Costa… - Viruses, 2023 - mdpi.com
Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes.
This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and …

Current progress toward synthetic routes and medicinal significance of quinoline

WS Shehab, MMK Amer, DA Elsayed, KK Yadav… - Medicinal Chemistry …, 2023 - Springer
Quinoline motifs are essential in several pharmacological active heterocyclic compounds
due to their various applications in medicinal and industrial chemistry. Furthermore, there …

Dilemma of immunosuppression and infection risk in systemic lupus erythematosus

J He, Z Li - Rheumatology, 2023 - academic.oup.com
Patients with SLE are at high risk of various infections as evidenced by a number of studies.
The main determinants of infection in SLE are disease activity, organ damage, and often …

Repurposing of drugs against methyltransferase as potential Zika virus therapies

R Shukla, A Chandra, A Kumar, P Kandpal… - Scientific Reports, 2023 - nature.com
In recent years, the outbreak of infectious disease caused by Zika Virus (ZIKV) has posed a
major threat to global public health, calling for the development of therapeutics to treat ZIKV …

Identification of potent Zika virus NS5 RNA-dependent RNA polymerase inhibitors combining virtual screening and biological assays

Y Chen, X Chi, H Zhang, Y Zhang, L Qiao… - International Journal of …, 2023 - mdpi.com
The Zika virus (ZIKV) epidemic poses a significant threat to human health globally. Thus,
there is an urgent need for developing effective anti-ZIKV agents. ZIKV non-structural protein …

Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

AK Kabi, M Pal, R Gujjarappa… - Journal of …, 2023 - Wiley Online Library
The novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused the
ongoing pandemic named COVID‐19 which causes a serious emergency on public health …

Much ado about nothing? Discrepancy between the available data on the antiviral effect of hydroxychloroquine in March 2020 and its inclusion in COVID-19 clinical …

N Vieux, Q Perrier, P Bedouch, O Epaulard - Public Health, 2023 - Elsevier
Objectives Many of the 2020 COVID-19 clinical trials included an (hydroxy) chloroquine ((H)
CQ) arm. We aimed to juxtapose the state of science before April 2020 regarding the …

Exploration of novel hexahydropyrrolo [1, 2-e] imidazol-1-one derivatives as antiviral agents against ZIKV and USUV

R Chen, R Francese, N Wang, F Li, X Sun, B Xu… - European Journal of …, 2023 - Elsevier
Zika virus (ZIKV) and Usutu virus (USUV) are two emerging flaviviruses mostly transmitted
by mosquitos. ZIKV is associated with microcephaly in newborns and the less-known USUV …

Identification of Zika virus NS2B-NS3 protease and NS5 polymerase inhibitors by structure-based virtual screening of FDA-approved drugs

W Ezzemani, H Altawalah, M Windisch… - Journal of …, 2023 - Taylor & Francis
Zika virus (ZIKV) is a mosquito-borne human flavivirus responsible that causing emergency
outbreaks in Brazil. ZIKV is suspected of causing Guillain-Barre syndrome in adults and …

[PDF][PDF] Zika virus: an arboviral disease

MA Tahir, K Hussain, A Abbas… - Zoonosis …, 2023 - uniquescientificpublishers.com
The Zika virus (ZIKV) has emerged as a serious threat to global health. To fully understand
the virus's epidemiology, virology, dynamics of transmission, clinical symptoms, implications …