The skin barrier and moisturization: function, disruption, and mechanisms of repair

J Rajkumar, N Chandan, P Lio, V Shi - Skin Pharmacology and …, 2023 - karger.com
Background: The anatomic layers of the skin are well-defined, and a functional model of the
skin barrier has recently been described. Barrier disruption plays a key role in several skin …

Recent advances in cellular and molecular mechanisms of IgE-mediated food allergy

JF Crespo, B Cabanillas - Food Chemistry, 2023 - Elsevier
Food allergy is a public health issue the prevalence of which is steadily increasing. New
discoveries have contributed to the understanding of the molecular and cellular mechanisms …

[HTML][HTML] Degranulation of mast cells as a target for drug development

BG Yang, AR Kim, D Lee, SB An, YA Shim, MH Jang - Cells, 2023 - mdpi.com
Mast cells act as key effector cells of inflammatory responses through degranulation. Mast
cell degranulation is induced by the activation of cell surface receptors, such as FcεRI …

The high dose of inulin exacerbated food allergy through the excess accumulation of short-chain fatty acids in a BABL/c mouse model

Q Xie, K Mu, C Chen, S Gu, D Luo, W Fu… - International journal of …, 2023 - Elsevier
Inulin dietary supplement is conventionally beneficial to gut health and can potentially
prevent food allergy (FA). This study aimed to determine how dietary inulin interventions at …

[HTML][HTML] Emerging role of alarmins in food allergy: an update on pathophysiological insights, potential use as disease biomarkers, and therapeutic implications

A Rizzi, E Lo Presti, R Chini, L Gammeri… - Journal of Clinical …, 2023 - mdpi.com
Food allergies are immuno-mediated adverse reactions to ingestion or contact with foods,
representing a widespread health problem. The immune response can be IgE-mediated …

The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice

B Yang, H Wilkie, M Das, M Timilshina… - Journal of Allergy and …, 2023 - Elsevier
Background Atopic dermatitis (AD) is characterized by TH 2-dominated skin inflammation
and systemic response to cutaneously encountered antigens. The TH 2 cytokines IL-4 and IL …

Strain matters in mouse models of peanut‐allergic anaphylaxis: Systemic IgE‐dependent and Ara h 2‐dominant sensitization in C3H mice

M Paolucci, V Homère… - Clinical & …, 2023 - Wiley Online Library
Background Peanut allergy accounts for the majority of food‐induced hypersensitivity
reactions and can lead to lethal anaphylaxis. Animal models can provide an insight into the …

[HTML][HTML] Epicutaneous sensitization and food allergy: preventive strategies targeting skin barrier repair—facts and challenges

A Dębińska, B Sozańska - Nutrients, 2023 - mdpi.com
Food allergy represents a growing public health and socio-economic problem with an
increasing prevalence over the last two decades. Despite its substantial impact on the …

Succinate and mitochondrial DNA trigger atopic march from atopic dermatitis to intestinal inflammation

S Wang, B Liu, J Huang, H He, L Zhou, Y He… - Journal of Allergy and …, 2023 - Elsevier
Background Atopic march has long been recognized as the progression from atopic
dermatitis (AD) to food allergy and asthma during infancy and childhood. However, effective …

[HTML][HTML] Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model

H Yamada, A Kaitani, K Izawa, T Ando… - Frontiers in …, 2023 - frontiersin.org
Background Patients with food allergy often suffer from atopic dermatitis, in which
Staphylococcus aureus colonization is frequently observed. Staphylococcus aureus δ-toxin …