Genetics of congenital heart disease

Y Zhao, W Deng, Z Wang, Y Wang, H Zheng, K Zhou… - Clinica Chimica …, 2023 - Elsevier
During embryonic development, the cardiovascular system and the central nervous system
exhibit a coordinated developmental process through intricate interactions. Congenital heart …

Brain‐wide mapping of efferent projections of glutamatergic (Onecut3+) neurons in the lateral mouse hypothalamus

M Zupančič, E Tretiakov, Z Máté, F Erdélyi… - Acta …, 2023 - Wiley Online Library
Aim This study mapped the spatiotemporal positions and connectivity of Onecut3+ neuronal
populations in the developing and adult mouse brain. Methods We generated fluorescent …

Machine Learning Analysis of Alzheimer's Disease Single-Cell RNA-Sequencing Data across Cortex and Hippocampus Regions

MG Krokidis, AG Vrahatis, K Lazaros… - Current Issues in …, 2023 - mdpi.com
Advancements in molecular biology have revolutionized our understanding of complex
diseases, with Alzheimer's disease being a prime example. Single-cell sequencing …

Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata

S Gonda, C Riedel, A Reiner, I Köhler… - Development, 2023 - journals.biologists.com
Neuronal differentiation is regulated by neuronal activity. Here, we analyzed dendritic and
axonal growth of Basket cells (BCs) and non-Basket cells (non-BCs) using sparse …

p75 neurotrophin receptor in pre-adolescent prefrontal PV interneurons promotes cognitive flexibility in adult mice

P Chehrazi, KKY Lee, M Lavertu-Jolin… - bioRxiv, 2023 - biorxiv.org
Parvalbumin (PV)-positive GABAergic cells provide robust perisomatic inhibition to
neighboring pyramidal neurons and regulate brain oscillations. Alterations in PV interneuron …

Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration

H Munguba, K Nikouei, H Hochgerner, P Oberst… - Neuron, 2023 - cell.com
Although cardinal cortical interneuron identity is established upon cell-cycle exit, it remains
unclear whether specific interneuron subtypes are pre-established, and if so, how their …

[HTML][HTML] The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice

P Chehrazi, KKY Lee, M Lavertu-Jolin, Z Abbasnejad… - Biological …, 2023 - Elsevier
Abstract Background Parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acidergic)
cells provide robust perisomatic inhibition to neighboring pyramidal neurons and regulate …