[HTML][HTML] Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

[HTML][HTML] Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression

J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …

[HTML][HTML] New insight into circRNAs: characterization, strategies, and biomedical applications

XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …

[HTML][HTML] CircRNAs in tumor immunity and immunotherapy: Perspectives from innate and adaptive immunity

LL Yu, Q Xiao, B Yu, QL Lv, ZQ Liu, JY Yin - Cancer Letters, 2023 - Elsevier
Tumor immunotherapy is a new therapeutic approach that has been evolving in the last
decade and has dramatically changed the treatment options for cancer. Circular RNAs …

[HTML][HTML] A Circular RNAs: Emerging roles and new insights in human cancers

Z He, Q Zhu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules formed by
mRNA exon back-splicing. Although the circRNA functions remain largely unknown, their …

Exosomal circRNAs in cancer: implications for therapy resistance and biomarkers

Z Lin, Y Ji, J Zhou, G Li, Y Wu, W Liu, Z Li, T Liu - Cancer Letters, 2023 - Elsevier
Despite the advances in cancer treatment in recent years, the development of resistance to
cancer therapy remains the biggest hurdle towards curative cancer treatments. Therefore …

[HTML][HTML] m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

Z Kong, Y Lu, Y Yang, K Chang, Y Lin, Y Huang… - Molecular Cancer …, 2023 - AACR
The pathologic significance of the circular RNA DDIT4 (circDDIT4), which is formed by
backsplicing at the 3′-untranslated region (UTR) with a 5′ splice acceptor site in exon 2 of …

[HTML][HTML] Functions of circular RNA in human diseases and illnesses

A Gu, DK Jaijyan, S Yang, M Zeng, S Pei, H Zhu - Non-coding RNA, 2023 - mdpi.com
Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently
closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free …

[HTML][HTML] Circular RNAs as biomarkers for lung cancer

A Sufianov, S Begliarzade, A Beilerli, Y Liang… - Non-coding RNA …, 2023 - Elsevier
Lung cancer is the leading cause of death and morbidity from malignant neoplasms
worldwide, and its poor prognosis places a heavy burden on patients. A large percentage of …