Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase …

Histone acetylation is important for the activation of gene transcription but little is known
about its direct read/write mechanisms. Here, we report cryogenic electron microscopy …

Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play
major roles in modulating the structure of chromatin and regulating transcription. Because of …

The histone acetyltransferase p300/CBP is composed of several conserved domains,
among which, the TAZ2 domain is known as a protein-protein interaction domain that binds …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that
induce the ternary complex formation between a protein-of-interest (POI) and an E3 ligase …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …