Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?

CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

Exosome-bearing hydrogels and cardiac tissue regeneration

H Amini, AR Namjoo, MT Narmi, N Mardi… - Biomaterials …, 2023 - spj.science.org
Background In recent years, cardiovascular disease in particular myocardial infarction (MI)
has become the predominant cause of human disability and mortality in the clinical setting …

Cardiac regeneration–Past advancements, current challenges, and future directions

A Pezhouman, NB Nguyen, M Kay, B Kanjilal… - Journal of Molecular and …, 2023 - Elsevier
Cardiovascular disease is the leading cause of mortality and morbidity worldwide. Despite
improvements in the standard of care for patients with heart diseases, including innovation …

Stem cell therapy for acute myocardial infarction: Mesenchymal Stem Cells and induced Pluripotent Stem Cells

D Clavellina, W Balkan, JM Hare - Expert opinion on biological …, 2023 - Taylor & Francis
Introduction Acute myocardial infarction (AMI) remains a leading cause of death in the
United States. The limited capacity of cardiomyocytes to regenerate and the restricted …

Effect of once versus twice intracoronary injection of allogeneic-derived mesenchymal stromal cells after acute myocardial infarction: BOOSTER-TAHA7 randomized …

A Attar, M Farjoud Kouhanjani, K Hessami… - Stem Cell Research & …, 2023 - Springer
Background Mesenchymal stromal cell (MSC) transplantation can improve the left
ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted …

Safety and outcomes analysis: transcatheter implantation of autologous angiogenic cell precursors for the treatment of cardiomyopathy

JR Schubart, A Zare, RM Fernandez-de-Castro… - Stem Cell Research & …, 2023 - Springer
Background Stem cell transplantation is an emerging therapy for severe cardiomyopathy,
proffering stem cell recruitment, anti-apoptosis, and proangiogenic capabilities. Angiogenic …

[HTML][HTML] The recent advances in cell delivery approaches, biochemical and engineering procedures of cell therapy applied to coronary heart disease

J Ma, W Wang, W Zhang, D Xu, J Ding, F Wang… - Biomedicine & …, 2023 - Elsevier
Cell therapy is an important topic in the field of regeneration medicine that is gaining
attention within the scientific community. However, its potential for treatment in coronary …

Microvascular obstruction identifies a subgroup of patients who benefit from stem cell therapy following ST-elevation myocardial infarction

SJ Davidson, J Roncalli, D Surder, R Corti… - American Heart …, 2023 - Elsevier
Background Microvascular obstruction (MVO) is associated with greater infarct size, adverse
left-ventricular (LV) remodeling and reduced ejection fraction following ST-elevation …

Preventive effect of bone marrow mononuclear cell transplantation on acute myocardial infarction-induced heart failure: a meta-analysis of randomized controlled trials

A Hosseinpour, H Hosseinpour, A Attar - Cardiovascular Drugs and …, 2023 - Springer
Purpose Heart failure (HF) is a major complication of acute myocardial infarction (AMI).
Transplantation of bone marrow mononuclear cells (BM-MNC) in the setting of AMI has been …

[HTML][HTML] Healing the ischaemic heart: a critical review of stem cell therapies

D Tonkin, A Yee-Goh, R Katare - Reviews in Cardiovascular Medicine, 2023 - imrpress.com
Ischaemic heart disease (IHD) remains the leading cause of mortality worldwide. Current
pharmaceutical treatments focus on delaying, rather than preventing disease progression …