The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Psychiatric disorders are often distinguished from neurological disorders in that the former
do not have characteristic lesions or findings from cerebrospinal fluid …

Autism spectrum disorders (ASDs) include a wide range of neurodevelopmental disorders.
Several reports showed that mutations in different high‐risk ASD genes lead to ASD …

Neuropsychiatric disorders affect a large proportion of the global population and there is an
urgent need to understand the pathogenesis and to develop novel and improved treatments …

The examination of post-mortem brain tissue suggests synaptic loss as a central
pathological hallmark of schizophrenia spectrum (SCZ), which is potentially related to …

Abstract Background Disruptions of SETBP1 (SET binding protein 1) on 18q12. 3 by
heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical …

Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …

Induced pluripotent stem cells (iPSCs) have entered an unprecedented state of
development since they were first generated. They have played a critical role in disease …

Defective Wnt signaling is found to be associated with various neurodegenerative diseases.
In the canonical pathway, the Frizzled receptor (Fzd) and the lipoprotein receptor‐related …