Importance Interventions to reduce severe brain injury risk are the prime focus in neonatal
clinical trials. Objective To evaluate multiple perinatal interventions across clinical settings …

Pulmonary fibrosis is a debilitating and life-limiting lung condition in which the damage-
response mechanisms of mixed-population cells within the lungs go awry. The tissue …

Approximately 11% of infants are born preterm, and complications of prematurity are the
most common cause of death in children aged under five years. Almost one million preterm …

Objective Assess mortality and neurodevelopmental outcomes at 2 years of corrected age in
children who participated in the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion …

Rationale: Immature control of breathing is associated with apnea, periodic breathing,
intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it is not clear …

High-risk preterm infants are affected by a higher incidence of cognitive developmental
deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a …

Background Very preterm infants often require respiratory support and are therefore
exposed to an increased risk of bronchopulmonary dysplasia (chronic lung disease) and …

Background Apnoea of prematurity (AOP) is one of the most common diagnoses among
preterm infants. AOP often leads to hypoxemia and bradycardia which are associated with …

Background Management strategies for preterm neonates with respiratory distress
syndrome include early initiation of continuous positive airway pressure (CPAP) and titration …

As survival of extremely preterm infants continues to improve, there is also an associated
increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of …