HIV/Mtb co-infection: from the amplification of disease pathogenesis to an “emerging syndemic”
JM Azevedo-Pereira, D Pires, M Calado, M Mandal… - Microorganisms, 2023 - mdpi.com
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …
responsible for millions of new infections each year; together, they cause high morbidity and …
[HTML][HTML] Understanding retroviral life cycle and its genomic RNA packaging
Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …
obligate parasites, their replication involves a series of steps during which the virus hijacks …
Structure-based stabilization of SOSIP Env enhances recombinant ectodomain durability and yield
The envelope glycoprotein (Env) is the main focus of human immunodeficiency virus type 1
(HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein …
(HIV-1) vaccine development due to its critical role in viral entry. Despite advances in protein …
Multivalent sialic acid materials for biomedical applications
Y Cao, W Song, X Chen - Biomaterials Science, 2023 - pubs.rsc.org
Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …
Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus
The HIV-1 genome encodes a small number of proteins with structural, enzymatic,
regulatory, and accessory functions. These viral proteins interact with a number of host …
regulatory, and accessory functions. These viral proteins interact with a number of host …
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7
The CD4 receptor, by stabilizing TCR-MHC II interactions, plays a central role in adaptive
immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds …
immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds …
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity
A Laumaea, L Marchitto, S Ding… - Cell reports, 2023 - cell.com
Summary HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4+
T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env …
T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env …
Development of animal models for emerging infectious diseases by breaking the barrier of species susceptibility to human pathogens
N Rong, J Liu - Emerging Microbes & Infections, 2023 - Taylor & Francis
Outbreaks of emerging infectious diseases pose a serious threat to public health security,
human health and economic development. After an outbreak, an animal model for an …
human health and economic development. After an outbreak, an animal model for an …
Cell-to-cell transmission of HIV-1 and HIV-2 from infected macrophages and dendritic cells to CD4+ T lymphocytes
M Calado, D Pires, C Conceição, R Ferreira… - Viruses, 2023 - mdpi.com
Macrophages (Mø) and dendritic cells (DCs) are key players in human immunodeficiency
virus (HIV) infection and pathogenesis. They are essential for the spread of HIV to CD4+ T …
virus (HIV) infection and pathogenesis. They are essential for the spread of HIV to CD4+ T …