Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses
SC Goulooze, PW Vis, EHJ Krekels… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Pharmacokinetic (PK)-Pharmacodynamic (PD) and exposure-
response (ER) modeling are critical parts of pediatric drug development. By integrating …
response (ER) modeling are critical parts of pediatric drug development. By integrating …
Diamorphine pharmacokinetics and conversion factor estimates for intranasal diamorphine in paediatric breakthrough pain: systematic review
Background Intranasal diamorphine is a potential treatment for breakthrough pain but few
paediatric data are available to assist dose estimation. Aim To determine an intranasal …
paediatric data are available to assist dose estimation. Aim To determine an intranasal …
Neonatal Pain: Significance, Assessment, and Management
JM Dawes, RF Howard - Neonatal Anesthesia, 2023 - Springer
The neonate exhibits unique responses to nociceptive inputs that are the result of immature
sensory and motor systems. Important functional differences in pain-processing mechanisms …
sensory and motor systems. Important functional differences in pain-processing mechanisms …
[PDF][PDF] Analgesic and sedative pharmacotherapy in asphyxiated neonates treated with therapeutic hypothermia: a cool retrospective study
J Straatman - 2023 - studenttheses.uu.nl
Background: Adequate pain management for asphyxiated neonates treated with therapeutic
hypothermia is fundamental to maximise the efficacy of this treatment. Multiple factors …
hypothermia is fundamental to maximise the efficacy of this treatment. Multiple factors …
[PDF][PDF] Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy
IC Lutz, K Allegaert, JN de Hoon, H Marynissen - academia.edu
Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …