Immune-related adverse effects of checkpoint immunotherapy and implications for the treatment of patients with cancer and autoimmune diseases

B Ibis, K Aliazis, C Cao, S Yenyuwadee… - Frontiers in …, 2023 - frontiersin.org
During the past decade, there has been a revolution in cancer therapeutics by the
emergence of antibody-based immunotherapies that modulate immune responses against …

Immune-mediated hepatitis induced by immune checkpoint inhibitors: Current updates and future perspectives

Z Liu, Y Zhu, H Xie, Z Zou - Frontiers in Pharmacology, 2023 - frontiersin.org
In recent years, cancer immunotherapy has made remarkable achievements. Immune
checkpoint inhibitors (ICIs) have been used successfully in several types of cancer in the …

Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis

TM Halsey, AS Thomas, T Hayase, W Ma… - Science translational …, 2023 - science.org
Immune checkpoint inhibitors (ICIs) target advanced malignancies with high efficacy but also
predispose patients to immune-related adverse events like immune-mediated colitis (IMC) …

[HTML][HTML] Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Y Zhou, YB Medik, B Patel, DB Zamler… - The Journal of …, 2023 - ncbi.nlm.nih.gov
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life
and continuation of therapy can be constrained by immune-related adverse events (irAEs) …

Biomarkers of immune checkpoint inhibitor response and toxicity: Challenges and opportunities

RS Goodman, S Jung, JM Balko… - Immunological …, 2023 - Wiley Online Library
Immune checkpoint inhibitors have transformed cancer therapy, but their optimal use is still
constrained by lack of response and toxicity. Biomarkers of response may facilitate drug …

Risk factors for immune checkpoint inhibitor–mediated cardiovascular toxicities

LI Yousif, EM Screever, D Versluis… - Current Oncology …, 2023 - Springer
Abstract Purpose of Review Immune checkpoint inhibitors (ICIs) have improved the field of
cancer, especially in patients with advanced malignancies. Nevertheless, cardiovascular …

Immune Checkpoint Inhibitors in Patients with Pre-existing Neurologic Autoimmune Disorders

R Aoun, D Gratch, D Kaminetzky, I Kister - Current Neurology and …, 2023 - Springer
Abstract Purpose of Review The use of immune checkpoint inhibitors (ICIs) for oncologic
indications is associated with immune-related adverse events (irAEs). Patients with pre …

The current treatment landscape of cutaneous squamous cell carcinoma

CY Chong, MS Goh, SV Porceddu, D Rischin… - American Journal of …, 2023 - Springer
Non-melanoma skin cancers (NMSCs) are the most common form of skin cancer worldwide.
The global incidence of cutaneous squamous cell carcinoma (CSCC) is rising, with an …

Hepatotoxicity of immune checkpoint inhibitors: What is Currently Known

C Zheng, S Huang, M Lin, B Hong, R Ni… - Hepatology …, 2023 - journals.lww.com
Background: This systematic review and network meta-analysis aimed to provide a complete
hepatotoxicity profile, hepatotoxicity spectrum, and safety ranking of immune checkpoint …

Immune checkpoint inhibitors in advanced cutaneous squamous cell carcinoma: real-world experience from a Canadian Comprehensive Cancer Centre

EC Koch Hein, M Vilbert, I Hirsch, M Fernando Ribeiro… - Cancers, 2023 - mdpi.com
Simple Summary The effectiveness and safety of immune checkpoint inhibitors in the
treatment of patients with advanced cutaneous squamous cell carcinoma were evaluated in …