Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

Glioblastoma (GBM) is an unmet clinical need characterized by a standard of care (SOC) 5‐
year survival rate of only 5%, and a treatment mostly palliative. Significant hurdles in GBM …

Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic
(ie, theranostic) potencies in translational oncology, and some agents have been further …

The present study was aimed to synthesize, characterize, and evaluate the angiopep-2
grafted PAMAM dendrimers (Den, G 3.0 NH2) with and without PEGylation for the targeted …

The blood–brain barrier (BBB) is a semipermeable system, and, therefore, most of the active
substances are poorly transported through this barrier, resulting in decreased therapeutic …

Neuronal cells made of soma, axon, and dendrites are highly compartmentalized and
possess a specialized transport system that can convey long-distance electrical signals for …

The site specific attachment of the reactive TMTHSI-click handle to the N-terminus of
peptides and proteins is described. The resulting molecular constructs can be used in strain …

In this chapter, the delivery of biomolecules such as oligonucleotides, proteins, peptides and
others by connection of the power of modern nanoparticles with the flexibility and efficacy of …

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Background: Radiosurgery has been recognized as a reasonable treatment for metastatic
brain tumors. Increasing the radiosensitivity and synergistic effects are possible ways to …