Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders

TC Santiago, L Parra, JV Nani… - Journal of …, 2023 - Wiley Online Library
The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety

S Gong, F Deng - Frontiers in Immunology, 2023 - frontiersin.org
Emotional disorders, including depression and anxiety, contribute considerably to morbidity
across the world. Depression is a serious condition and is projected to be the top contributor …

Associations between mental health, blood pressure and the development of hypertension

HL Schaare, M Blöchl, D Kumral, M Uhlig… - Nature …, 2023 - nature.com
Multiple studies have reported a link between mental health and high blood pressure with
mixed or even contradictory findings. Here, we resolve those contradictions and further …

Associations between β-blockers and psychiatric and behavioural outcomes: a population-based cohort study of 1.4 million individuals in Sweden

Y Molero, S Kaddoura, R Kuja-Halkola, H Larsson… - PLoS …, 2023 - journals.plos.org
Background β-blockers are widely used for treating cardiac conditions and are suggested for
the treatment of anxiety and aggression, although research is conflicting and limited by …

Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects

C Carnovale, C Perrotta, S Baldelli… - Cardiovascular …, 2023 - academic.oup.com
A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

The association between antihypertensive medications and mental health outcomes among Syrian war refugees with stress and hypertension

O Gammoh, MH Bjørk, OA Al Rob, AR AlQudah… - Journal of …, 2023 - Elsevier
Background Little is known about the association between antihypertensive drugs with
mental health outcomes. We examined the association between the antihypertensive …

Episodic migraine and psychiatric comorbidity: a narrative review of the literature

A George, MT Minen - Current Pain and Headache Reports, 2023 - Springer
Abstract Purpose of Review We evaluate the evolving evidence of psychiatric comorbidities
associated with episodic migraine. Utilizing recent research publications, we aim to assess …

[HTML][HTML] Can chronic therapeutic drug use by the elderly affect Alzheimers disease risk and rate of progression?

R Franco, J Serrano-Marín - Exploration of Neuroprotective …, 2023 - explorationpub.com
There is no approved drug capable of halting the progression of the most prevalent
neurodegenerative disorders, namely Alzheimer's disease (AD) and Parkinson's disease …

The renin-angiotensin system, emotional stress and anxiety

MAP Fontes, LM Kangussu, AC Simões-e-Silva - Angiotensin, 2023 - Elsevier
Emotional stress is the hidden force behind innumerous conditions, from an easily
identifiable cardiac arrhythmia to far more complex phenomena such as depression or …

Distinct effects of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on major depressive disorder: A nationwide cohort study

JM Lee, S Choi, S Jeong, JS Son, SJ Park… - Asian Journal of …, 2023 - Elsevier
2. Methods From the Korean National Health Insurance Service-Health Screening Cohort
2002–2013 database, we identified 134,948 participants who were newly diagnosed …