Impaired wound healing in chronic wounds has been a significant challenge for clinicians
and researchers for decades. Traditional herbal medicine (THM) has a long history of …

Macrophages as innate immune cells with great plasticity are of great interest for cell
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …

Chronic hypoxia and ischemia make diabetic wounds non‐healing. Cellular functions of
diabetic chronic wounds are inhibited under a pathological environment. Therefore, this …

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have
debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress …

Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

Diabetic wound (DW) is characterized by elevated pro-inflammatory cytokines and cellular
dysfunction consistent with elevated reactive oxygen species (ROS) levels. Recent …

Background Despite recent advances in wound healing products, phytochemicals have
been considered promising and attractive alternatives. Carvacrol (CAR), a natural phenolic …

Recent studies manifest an increase of inflammatory diseases at an alarming rate due to gut
microbiota dysbiosis, genetic and other environmental factors. Lactic acid bacteria (LAB) are …

Background Diabetic wounds represent a severe clinical challenge in which impaired M2
macrophage polarization and continuous macrophage glycolysis play crucial roles …

Nonhealing diabetic wounds, with persistent inflammation and damaged vasculature, have
failed conventional treatments and require comprehensive interference. Here, inspired by …