Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used
in the treatment of mental disorders because of its antidepressive, anxiolytic, and …

Immune checkpoint blockade therapy is an important advance in cancer treatment, and the
representative drugs (PD-1/PD-L1 antibodies) have greatly improved clinical outcomes in …

Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

Combination therapies to induce mixed-type cell death and synthetic lethality have the
potential to overcome drug resistance in cancer. In this study, we demonstrated that the …

With more than a million deaths each year, breast cancer is the top cause of death in
women. Around 70% of breast cancers are hormonally responsive. Although several …

Hepatocellular carcinoma (HCC) is one of the most common digestive malignancies. HCC It
ranges as the fifth most common cause of cancer mortality worldwide. While The prognosis …

Ovarian cancer (OC) is characterized by high mortality rates owing to late diagnosis and
resistance to chemotherapy. Autophagy and metabolism play essential roles in the …

Degrader technologies provide unprecedented strategies to tackle diseases caused by
pathogenic proteins that are difficult to target by the traditional inhibitor approach. One …

Autophagy, the process that enables the recycling and degradation of cellular components,
is essential for homeostasis, which occurs in response to various types of stress. Autophagy …

Autophagy, a homeostatic mechanism, is crucial in maintaining normal cellular function.
Although dysregulation of autophagic processes is recognized in certain diseases, it is …